Publications

2025

Castillo F, Kern BC, Villablanca EJ. B cells in inflammatory bowel disease. Immunology Letters. 2025 Aug, PMID: 40845931

Morales Castro RA, Kern BC, Díaz-Basabe A, Meinen ER, Zhao D, Zhou Y, Castillo F, Monasterio G, Farcas V, Chávez MN, Fransson J, Villablanca EJ. A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as major modulators of mucosal healing Mucosal Immunol. 2025 Aug, PMID: 40252728

Villablanca EJ. Organismal mucosal immunology: A perspective through the eyes of game theory. Mucosal Immunol. 2025 Feb, PMID: 39672543

Villablanca EJ. Anyone can cook, but only the fearless can be a great chef. Immunol Cell Biol. 2025 Feb, PMID: 39607289

Das S, Parigi SM, Luo X, Fransson J, Kern BC, Okhovat A, Diaz OE, Sorini C, Czarnewski P, Webb AT, Morales RA, Lebon S, Monasterio G, Castillo F, Tripathi KP, He N, Pelczar P, Schaltenberg N, De la Fuente M, López-Köstner F, Nylén S, Larsen HL, Kuiper R, Antonson P, Hermoso MA, Huber S, Biton M, Scharaw S, Gustafsson JÅ, Katajisto P, Villablanca EJ. Liver X receptor unlinks intestinal regeneration and tumorigenesis. Nature. 2025 Jan, PMID: 39567700

2024

Hausmann A, Sandu I, Bechara R, Eidsmo L, Liston A, Naik S, Scott CL, Villa M, Villablanca EJ, Muñoz‐Wolf N. Researcher Reflections—Inspiring Paths in Academia. Eur J Immunol. 2025 Dec: doi.org/10.1002

2023

Pennacchietti F, Alvelid J, Morales RA, Damenti M, Ollech D, Oliinyk OS, Shcherbakova DM, Villablanca EJ, Verkhusha VV, Testa I. Blue-shift photoconversion of near-infrared fluorescent proteins for labeling and tracking in living cells and organisms. Nat commun. 2023 Dec 19, PMID:38114484

Pérez-Jeldres T, Magne F, Ascui G, Alvares D, Orellana M, Alvarez-Lobos M, Hernandez-Rocha C, Azocar L, Aguilar N, Espino A, Estela R, Escobar S, Zazueta A, Baez P, Silva V, De La Vega A, Arriagada E, Pavez-Ovalle C, Díaz-Asencio A, Travisany D, Miquel JF, Villablanca EJ, Kronenberg M, Bustamante ML. Amerindian ancestry proportion as a risk factor for inflammatory bowel diseases: results from a Latin American Andean cohort. Front Med (Lausanne). 2023 Oct 27, PMID: 37964883

Sorini C, Cardoso RF, Tripathi KP, Mold JE, Diaz OE, Holender Y, Kern BC, Czarnewski P, Gagliani N, Villablanca EJ. Intestinal damage is required for the pro-inflammatory differentiation of commensal CBir1-specific T cells. Mucosal Immunol. 2023 Nov 10, PMID: 37952848

Devarakonda S, Thorsell A, Hedenström P, Rezapour A, Heden L, Banerjee S, Johansson MEV, Birchenough G, Toft Morén A, Gustavsson K, Skokic V, Pettersson VL, Sjöberg F, Kalm M, Al Masri M, Ekh M, Fagman H, Wolving M, Perkins R, Morales RA, Castillo F, Villablanca EJ, Yrlid U, Bergmark K, Steineck G, Bull C. Low-grade intestinal inflammation two decades after pelvic radiotherapy. EBioMedicine. 2023 Aug 22, PMID: 37480626

Kokkinou E, Soini T, Pandey RV, van Acker A, Theorell J, Czarnewski P, Kvedaraite E, Vandamme N, Lourda M, Sorini C, Weigel W, Carrasco A, Tibbitt CA, Schlums H, Lindforss U, Nordenvall C, Ljunggren M, Ideström M, Svensson M, Henter JI, Villablanca EJ, Bryceson YT, Rolandsdotter H, Mjösberg J. The single-cell transcriptional landscape of innate and adaptive lymphocytes in pediatric-onset colitis. Cell Rep Med. 2023 May 16, PMID: 37160121

Scharaw S, Sola-Carvajal A, Belevich I, Webb AT, Das S, Andersson S, Pentinmikko N, Villablanca EJ, Goldenring JR, Jokitalo E, Coffey RJ, Katajisto P. Golgi organization is a determinant of stem cell function in the small intestine. bioRxiv. 2023 March 24, PMID: 36993731

Sorini C, Tripathi KP, Wu S, Higdon SM, Wang J, Cheng L, Banerjee S, Reinhardt A, Kreslavsky T, Thorell A, Engstrand L, Du J, Villablanca EJ. Metagenomic and single-cell RNA-Seq survey of the Helicobacter pylori-infected stomach in asymptomatic individuals. JCI Insight. 2023 Feb 22, PMID: 36810249

2022

Frede, A., Czarnewski, P., Monasterio, G., Tripathi, K. P., Bejarano, D. A., Ramirez Flores, R. O., Sorini, C., Larsson, L., Luo, X., Geerlings, L., Novella-Rausell, C., Zagami, C., Kuiper, R., Morales, R. A., Castillo, F., Hunt, M., Mariano, L. L., Hu, Y. O. O., Engblom, C., Lennon-Duménil, AM., Mittenzwei, R., Westendorf, A.M., Hövelmeyer, N., Lundeberg, J., Saez-Rodriguez, J., Schlitzer, A., Das, S., Villablanca EJ. B cell expansion hinders the stroma-epithelium regenerative cross talk during mucosal healing. Immunity. 2022 Nov 29, PMID: 36462502

Borm, L. E., Mossi Albiach, A., Mannens, C. C. A., Janusauskas, J., Özgün, C., Fernández-García, D., Hodge, R., Castillo, F., Hedin, C. R. H., Villablanca EJ, Uhlén, P., Lein, E. S., Codeluppi, S., & Linnarsson, S. Scalable in situ single-cell profiling by electrophoretic capture of mRNA using EEL FISH. Nat Biotechnol. 2022 Sep 22, PMID:36138169

Morales, R. A., Rabahi, S., Diaz, O. E., Salloum, Y., Kern, B. C., Westling, M., Luo, X., Parigi, S. M., Monasterio, G., Das, S., Hernández, P. P., & Villablanca EJ. Interleukin-10 regulates goblet cell numbers through Notch signaling in the developing zebrafish intestine. Mucosal Immunol. 2022 May, PMID: 35840681

Melhem H., Kaya B., Kaymak T., Wuggening P., Flint E., Roux J., Oost KC, Weder CC., Balmer ML., Wasler JC., Morales RA., Riedel CU., Liberali P., Villablanca EJ  & Niess JH. Epithelial GPR35 protects from Citrobacter rodentium infection by preserving goblet cells and mucosal barrier integrity. Mucosal Immunol.2022 Mar, PMID: 35264769

Parigi SM., Larsson L, Das S, Ramirez-Flores RO, Frede A, Tripathi KP, Diaz OE, Selin K, Morales R, Luo X, Monasterio G., Engblom C., Gagliani N., Saez-Rodriguez J., Lundeberg J. & Villablanca EJ. The spatial transcriptomic landscape of the healing mouse intestine following damage. Nat Commun. 2022 Feb 11, PMID: 35149721

Villablanca EJ, Selin K., & Hedin CRH. Mechanisms of mucosal healing: treating inflammatory bowel disease without immunosuppression? Nat Rev Gastroenterol Hepatol. 2022 Aug, PMID: 35440774

2021

Luo X. & Villablanca EJ. (2021) Type 2 immunity in in intestinal homeostasis and inflammatory bowel diseases. Biochem Soc Trans. 2021 Nov 1, PMID:34581755

Monasterio G., Castillo F. & Villablanca EJ. (2021) Cell trafficking in the intestinal mucosa in the healthy and inflamed gut.  Chapter in book “Cell movement in health and disease”. Elsevier Book Chapter.

Classon C., Li M, Clavero AL, Ma J, Feng X, Tibbitt C, Stark JM, Cardoso R, Rinqvist E, Boon L., Villablanca EJ, Rothfuchs A., Eidsmo L., Coquet J, & Nylen S. Intestinal helminth infection transforms the CD4+ T cell composition of the skin. Mucosal Immunol. 2021 Dec 20, PMID: 34931000

Diaz OE, Sorini C, Morales RA, Luo X, Frede A, Krais AM, Chávez MN, Wincent E, Das S., & Villablanca EJ. Perfluorooctanesulfonic acid modulates barrier function and systemic T cell homeostasis during intestinal inflammation. Dis Model Mech.. 2021 Dec 1, PMID: 34792120

Rivera C., Randrian V., Richer W., Gerber Y., Delgado MG., Chikinia A., Frede A., Sorini C., Mauring M., Parigi SM., Goudot C., Krndija D., Cabeza-Cabrerizo M., Baulande S., Lameiras S., Guermonprez P., Reis e Sousa C., Lecuit M., Moreau HD., Helft J., Vignjevic DM., Villablanca EJ, AM Lennon-Dumenil. Epithelial colonization promotes the functional diversification of gut dendritic cells. Immunity. 2021 Dec 8, PMID: 34910930

Sorini C. & Villablanca EJ.ILC damage, and I’ll repair it. Immunity.2021 Jun 8, PMID: 34107265

Selin K., Hedin C. & Villablanca EJ.Immunological networks defining the heterogeneity of inflammatory bowel diseases. J Crohns Colitis.2021 Nov 8, PMID: 33959743

Evren E, Ringqvist E., Tripathi KP., Sleiers N., Rives IC, Alisjahbana A, Gao Y, Sarhan D, Halle T, Sorini C, Lepzien R, Marquardt N, Michaëlsson J, Smed-Sörensen A, Botling J, Karlsson M, Villablanca EJ, Willinger T. Mapping the monocytic origin of lung macrophages identifies new pathways of human macrophage ontogeny. Immunity. 2020 Dec 23, PMID: 33382972

Fraga-Silva TFC, Nishiyama-Mimura LA, Cardoso de Oliveira LR, dos Santos Toledo JH, Borim PA, Zorzella-Pezavento SFG, Peres Alonso D, Martins Ribolla PE, Ferreira de Oliveira CA, Morais da Fonseca D, Villablanca EJ, Sartori A. Selenization of S. cerevisiae increases its protective potential in experimental autoimmune encephalomyelitis by triggering an intestinal immunomodulatory loop. Sci Rep.2020 Dec 17, PMID: 33335128

Monasterio G., Castillo F., Astorga J., Hoare A., Terraza-Aguirre C., Cafferata EA., Villablanca EJ, Vernal R. O-polysaccharide Plays a Major Role on the Virulence and Immunostimulatory Potential of Aggregatibacter actinomycetemcomitans During Periodontal Infection. Front Immunol.2020 Oct 30, PMID: 33193431

Parigi SM, Das S, Frede A, Cardoso RF, Tripathi KP, Doñas C, Yue OO, Antonson P, Engstrand L, Gustafsson JA, & Villablanca EJ.  Liver X receptor regulates Th17 and RORgt+ Treg cells by distinct mechanisms. Mucosal Immunol. 2021 Mar, PMID: 32681027

Rao A, Strauss O, Kokkinou E, Bruchard M, Tripathi K, Schlums H, Carrasco A, Mazzurana L, Konya V, Villablanca EJ, Björkström N, Lindforss U, Spits H, & Mjösberg J. Cytokines regulate the antigen-presenting characteristics of human circulating and tissue-resident intestinal ILCs. Nat Commun. 2020 Apr 27, PMID: 32341343

Kaya B, Doñas C, Wuggenig P, Diaz O, Morales R, Melhem H, Swiss IBD Cohort, Hernández PP, Kaymak T, Das S, Hruz P, Ayata CK, Villablanca EJ*, Niess JH*. Lysophosphatidic acid-mediated GPR35 signaling in CX3CR1+ macrophages regulates the intestinal cytokine milieu. Cell Rep. 2020 Aug 4, PMID: 32755573

Stakenborg M., Verstockt B, Meroni E, Goverse G, Verstockt S, Di Matteo M, Czarnewski P, Villablanca EJ, Ferrante M, Boeckxstaens GE, Mazzone M., Vermeire S., Matteoli G. Neutrophilic HGF-MET signaling exacerbates intestinal inflammation. J Crohns Colitis.2020 June 17, PMID: 32556102

Perez-Jeldres T., Alvarez-Lobos M., Rivera-Nieves J. & Villablanca EJ. The cell circuitry of Ulcerative Colitis, a new view for a highly complex disease. Gastroenterology. 2020 April, PMID: 32068021

Rao A., Strauss O., Kokkinou E, Bruchard M., Tripathi K., Schlums H, Carrasco A., Mazzurana L., Konya V, Villablanca EJ, Bjorkstrom N., Lindforss U., Spits H., and Mjosberg J. Cytokines regulate the antigen-presenting characteristics of human circulating and tissue-resident intestinal ILCs. Nat Commun. 2020 Apr 27, PMID: 32341343

Diaz OE., Xue S., Luo X., Nava J., Appelblom A., Morales RA., Das, S. & Villablanca EJ. Retinoic acid induced cytokines are selectively modulated by liver X receptor in zebrafish. Reprod Toxicol. 2020 April, PMID: 32109521

Phad GE, Pushparaj P, Tran K, Dubrovskaya V, Àdori M, Martinez-Murillo P, Vázquez Bernat N, Singh S, Dionne G, O’Dell S, Bhullar K, Narang S, Sorini C, Villablanca EJ, Sundling C, Murrell B, Mascola JR, Shapiro L, Pancera M, Martin M, Corcoran M, Wyatt RT, Karlsson Hedestam GB. Extensive dissemination and intraclonal maturation of HIV Env vaccine-induced B cell responses. J Exp Med., 2020 Feb 3, PMID 3170480.

Diaz O.E., Morales R.A., Das S., Villablanca EJ. Experimental Models of Intestinal Inflammation: Lessons from Mouse and Zebrafish. Molecular Genetics of Inflammatory Bowel Disease. Springer, Cham. Book Chapter., 2020.

2019

Siracusa F, Schaltenberg N, Villablanca EJ, Huber S, Gagliani N. Dietary Habits and Intestinal Immunity: From Food Intake to CD4+ T H Cells. Front Immunol., 2019 Jan 15, PMID 30697217.

Czarnewski P, Parigi SM, Sorini C, Diaz OE, Das D, Gagliani N, Villablanca EJ. Conserved transcriptomic profile between mouse and humans allows temporal dynamic visualization of IBD-risk genes and unsupervised patient stratification. Nat. Commun. 2019 Jun 28, PMID: 31253778

Seitz C, Liu S, Klocke K, Joly AL, Czarnewski P, Tibbitt CA, Parigi SM, Westerberg LS, Coquet JM, Villablanca EJ, Wing K, Andersson J. Multi-faceted inhibition of dendritic cell function by CD4+Foxp4+ regulatory T cells. J Autoimmun., 2019 Jan 4, PMID: 30616979

2018

Sorini C, Cardoso RF, Gagliani N, Villablanca EJ. Commensal Bacteria-Specific CD4+ T Cell Responses in Health and Disease. Front Immunol., 2018 Nov 20, PMID 30524431

Brockmann L, Soukou S, Steglich B, Czarnewski P, Zhao L, Wende S, Bedke T, Ergen C, Manthey C, Agalioti T, Geffken M, Seiz O, Parigi S, Sorini C, Geginat J, Fujio K, Jacobs T, Roesch T, Izbicki J, Lohse A, Flavell R, Krebs C, Gustafsson JA, Antonson P, Roncarolo MG, Villablanca EJ, Gagliani N., and Huber S. Molecular and functional heterogeneity of IL-10-producing CD4+ T cells. Nat Commun.2018 Dec 21, PMID: 30575716

Lindheim L, Manti M, Fornes R, Bashir M, Czarnewski P, Diaz O, Seifert M, Engstrand L, Villablanca EJ, Obermayer-Pietsch B, and Stener-Victorin E. Reproductive and behavior dysfunction induced by maternal androgen exposure and obesity is not gut microbiome-mediated. J Endocr Soc.2018 Oct 15, PMID: 30534630

Parada-Kusz MM, Clatworthy A, Hagedorn E, Penaranda C, Nair A, Henninger JE, Ernst C, Li B, Riquelme R, Jijon H, Villablanca EJ , Zon L, Hung D, and Allende ML. Zebrafish Hematopoietic Tissue Chimeric Embryos for Hematopoiesis and Host-Pathogen Interaction Studies. Diseases Models & Mech.2018 Nov 5, PMID: 30266803

Das S, Doñas C, Akeus P, Quiding-Järbrink M, Mora JR, Villablanca EJ . b7 integrins contribute to intestinal tumor growth in mice. Plos One.2018 Sep 20, PMID: 30235302

Agalioti T, Villablanca EJ, Huber S & Gagliani N. TH17 cell plasticity: The role of dendritic cells and molecular mechanisms. J Autoimmun.2018 Feb, PMID: 29371049

Emgård J., Kammoun H., Garcia-Cassani B., Chesné J., Parigi SM., Jacob JM., Evren E., Das S., Czarnewski P., Sleiers N., Melo-Gonzalez F., Pelczar P., Kvedaraite E., Svensson M., Hepworth M., Huber S., Peduto L., Villablanca EJ., Veiga-Fernandes H., Pereira JP., Flavell RA., Willinger T. Oxysterol sensing through the receptor GPR183 promotes the lymphoid tissue-inducing function of innate lymphoid cells and colonic inflammation. Immunity. 2018 Jan 16, PMID: 29343433

Konya V, Czarnewski P, Forkel M, Rao A, Kokkinou E, Villablanca EJ, Almer S, Lindforss U, Friberg D, Höög C, Bergman P, Mjösberg J. Vitamin D downregulates the IL-23 receptor pathway in human mucosal ILC3. J Allergy Clin Immunol. 2018 Jan, PMID: 28433688

Parigi SM, Czarnewski P, Das S, Steeg C, Brockmann L, Fernandez-Gaitero S, Yman V, Forkel M, Höög C, Mjösberg J, Westerberg L, Färnert A, Huber S, Jacobs T, Villablanca EJ. Flt3 ligand expands bona fide innate lymphoid cell precursors in vivo. Sci Rep.  2018 Jan 9, PMID: 2931768

2017

Mucosal Immunol. Intestinal epithelial cell-specific RARα depletion results in aberrant epithelial cell homeostasis and underdeveloped immune system. Jijon HB, Suarez-Lopez L, Diaz OE, Das S, De Calisto J, Yaffe MB, Pittet MJ, Mora JR, Belkaid Y, Xavier RJ, Villablanca EJ. 2017 Nov 15, PMID: 29139475

Mucosal Immunol. Retinoic acid takes effector T cells to the gallows: P2X7, the molecular hangman. Das S, Villablanca EJ. 2017 Jul, PMID: 28051090

Mol Cell Proteomics. Tracing Cellular Origin of Human Exosomes Using Multiplex Proximity Extension Assays. Larssen P, Wik L, Czarnewski P, Eldh M, Löf L, Ronquist KG, Dubois L, Freyhult E, Gallant CJ, Oelrich J, Larsson A, Ronquist G, Villablanca EJ, Landegren U, Gabrielsson S, Kamali-Moghaddam M. 2017 Mar, PMID: 28111361

Nutrients. Retinoic Acid and Its Role in Modulating Intestinal Innate Immunity. Czarnewski P, Das S, Parigi SM, Villablanca EJ. 2017 Jan 13, PMID: 28098786

Immunity. Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk. Lassen KG, McKenzie CI, Mari M, Murano T, Begun J, Baxt LA, Goel G, Villablanca EJ, Kuo SY, Huang H, Macia L, Bhan AK, Batten M, Daly MJ, Reggiori F, Mackay CR, Xavier RJ. 2016 Jun 21, PMID: 27287411

Annu Rev Immune. Mechanisms of Pediatric Inflammatory Bowel Disease. Peloquin JM, Goel G, Villablanca EJ, Xavier RJ. 2016 May 20, PMID: 27168239