2020
Parigi SM, Das S, Frede A, Cardoso RF, Tripathi KP, Doñas C, Yue OO, Antonson P, Engstrand L, Gustafsson JA, & Villablanca EJ. Liver X receptor regulates Th17 and RORgt+ Treg cells by distinct mechanisms. Mucosal Immunology. In Press.
Rao A, Strauss O, Kokkinou E, Bruchard M, Tripathi K, Schlums H, Carrasco A, Mazzurana L, Konya V, Villablanca EJ, Björkström N, Lindforss U, Spits H, & Mjösberg J. Cytokines regulate the antigen-presenting characteristics of human circulating and tissue-resident intestinal ILCs. Nature Communications, 11, 2049 (2020).
Kaya BDoñas CWuggenig P Diaz OMorales RMelhem HSwiss IBD CohortHernández PPKaymak TDas SHruz PAyata CKVillablanca EJ*Niess JH*. Lysophosphatidic acid-mediated GPR35 signaling in CX3CR1+ macrophages regulates the intestinal cytokine milieu. Cell Reports, In Press. (*) Equal contribution
Stakenborg M., Verstockt B, Meroni E, Goverse G, Verstockt S, Di Matteo M, Czarnewski P, Villablanca EJ., Ferrante M, Boeckxstaens GE, Mazzone M., Vermeire S., Matteoli G. Neutrophilic HGF-MET signaling exacerbates intestinal inflammation JCC. 2020. June 17. PMID: 32556102
Perez-Jeldres T., Alvarez-Lobos M., Rivera-Nieves J. & Villablanca EJ. The cell circuitry of Ulcerative Colitis, a new view for a highly complex disease. Gastroenterology. 2020. April; 158(5), 1506-1508.
Rao A., Strauss O., Kokkinou E, Bruchard M., Tripathi K., Schlums H, Carrasco A., Mazzurana L., Konya V, Villablanca EJ, Bjorkstrom N., Lindforss U., Spits H., and Mjosberg J. Cytokines regulate the antigen-presenting characteristics of human circulating and tissue-resident intestinal ILCs. Nature Communications. 2020. In Press.
Diaz OE., Xue S., Luo X., Nava J., Appelblom A., Morales RA., Das, S. & Villablanca EJ. Retinoic acid induced cytokines are selectively modulated by liver X receptor in zebrafish. Rep. Tox. 2020. April; 93. 163-168
Phad GE, Pushparaj P, Tran K, Dubrovskaya V, Àdori M, Martinez-Murillo P, Vázquez Bernat N, Singh S, Dionne G, O’Dell S, Bhullar K, Narang S, Sorini C, Villablanca EJ , Sundling C, Murrell B, Mascola JR, Shapiro L, Pancera M, Martin M, Corcoran M, Wyatt RT, Karlsson Hedestam GB. Extensive dissemination and intraclonal maturation of HIV Env vaccine-induced B cell responses. J Exp Med., 2020 Feb 3;217(2). pii: e20191155. doi: 10.1084/jem.20191155. PMID 3170480.
Diaz O.E., Morales R.A., Das S., Villablanca E.J . Experimental Models of Intestinal Inflammation: Lessons from Mouse and Zebrafish. Molecular Genetics of Inflammatory Bowel Disease. Springer, Cham. Book Chapter., 2020.
2019
Siracusa F, Schaltenberg N, Villablanca EJ , Huber S, Gagliani N. Dietary Habits and Intestinal Immunity: From Food Intake to CD4+ T H Cells. Front Immunol., 2019 Jan 15;9:3177. doi: 10.3389/fimmu.2018.03177. eCollection 2018. PMID 30697217.
Czarnewski P, Parigi SM, Sorini C, Diaz OE, Das D, Gagliani N, Villablanca EJ . Conserved transcriptomic profile between mouse and humans allows temporal dynamic visualization of IBD-risk genes and unsupervised patient stratification. Nat. Communications, 2019 Online June 28, doi.org/10.1038/s41467-019-10769-x.
Seitz C, Liu S, Klocke K, Joly AL, Czarnewski P, Tibbitt CA, Parigi SM, Westerberg LS, Coquet JM, Villablanca EJ , Wing K, Andersson J. Multi-faceted inhibition of dendritic cell function by CD4+Foxp4+ regulatory T cells. J. Autoimmun., 2019 Jan 4. pii: S0896-8411(18)30438-4. doi: 10.1016/j.jaut.2018.12.002.
2018
Sorini C, Cardoso RF, Gagliani N, Villablanca EJ. Commensal Bacteria-Specific CD4+ T Cell Responses in Health and Disease. Front Immunol., 2018 Nov 20;9:2667. doi: 10.3389/fimmu.2018.02667. eCollection 2018. Review. PMID 30524431
Brockmann L, Soukou S, Steglich B, Czarnewski P, Zhao L, Wende S, Bedke T, Ergen C, Manthey C, Agalioti T, Geffken M, Seiz O, Parigi S, Sorini C, Geginat J, Fujio K, Jacobs T, Roesch T, Izbicki J, Lohse A, Flavell R, Krebs C, Gustafsson JA, Antonson P, Roncarolo MG, Villablanca EJ ,Gagliani N., and Huber S. Molecular and functional heterogeneity of IL-10-producing CD4+ T cells. Nat. Communications, 2018 Dec 21;9(1):5457. doi: 10.1038/s41467-018-07581-4.
Lindheim L, Manti M, Fornes R, Bashir M, Czarnewski P, Diaz O, Seifert M, Engstrand L,, Villablanca EJ , Obermayer-Pietsch B, and Stener-Victorin E. Reproductive and behavior dysfunction induced by maternal androgen exposure and obesity is not gut microbiome-mediated. J. Endocrine Society, 2018 Oct 15;2(12):1363-1380. doi: 10.1210/js.2018-00266.
Parada-Kusz MM, Clatworthy A, Hagedorn E, Penaranda C, Nair A, Henninger JE, Ernst C, Li B, Riquelme R, Jijon H, Villablanca EJ , Zon L, Hung D, and Allende ML. Zebrafish Hematopoietic Tissue Chimeric Embryos for Hematopoiesis and Host-Pathogen Interaction Studies. Diseases Models & Mech., 2018 Nov 5;11(11). pii: dmm034876. doi: 10.1242/dmm.034876.
Das S, Doñas C, Akeus P, Quiding-Järbrink M, Mora JR, Villablanca EJ . b7 integrins contribute to intestinal tumor growth in mice. Plos ONE, 2018 Sep 20;13(9):e0204181 doi: 10.1371/journal.pone.0204181.
Agalioti T, Villablanca EJ, Huber S & Gagliani N. TH17 cell plasticity: The role of dendritic cells and molecular mechanisms. J. Autoimmun., 2018 Feb;87:50-60 doi: 10.1016/j.jaut.2017.12.003. Epub 2018 Jan 19 Review PMID: 29371049
Emgård J., Kammoun H., Garcia-Cassani B., Chesné J., Parigi SM., Jacob JM., Evren E., Das S., Czarnewski P., Sleiers N., Melo-Gonzalez F., Pelczar P., Kvedaraite E., Svensson M., Hepworth M., Huber S., Peduto L., Villablanca EJ., Veiga-Fernandes H., Pereira JP., Flavell RA., Willinger T. Oxysterol sensing through the receptor GPR183 promotes the lymphoid tissue-inducing function of innate lymphoid cells and colonic inflammation. Immunity. 2018 Jan 16;48(1):120-132.e8. doi: 10.1016/j.immuni.2017.11.020.
Konya V, Czarnewski P, Forkel M, Rao A, Kokkinou E, Villablanca EJ, Almer S, Lindforss U, Friberg D, Höög C, Bergman P, Mjösberg J. Vitamin D downregulates the IL-23 receptor pathway in human mucosal ILC3. J Allergy Clin Immunol. 2018 Jan;141(1):279-292. doi: 10.1016/j.jaci.2017.01.045. Epub 2017 Apr 20.
Parigi SM, Czarnewski P, Das S, Steeg C, Brockmann L, Fernandez-Gaitero S, Yman V, Forkel M, Höög C, Mjösberg J, Westerberg L, Färnert A, Huber S, Jacobs T, Villablanca EJ. Flt3 ligand expands bona fide innate lymphoid cell precursors in vivo. Sci Rep. 2018 Jan 9;8(1):154. doi: 10.1038/s41598-017-18283-0. PMID: 2931768
2017
Mucosal Immunol. Intestinal epithelial cell-specific RARα depletion results in aberrant epithelial cell homeostasis and underdeveloped immune system. Jijon HB, Suarez-Lopez L, Diaz OE, Das S, De Calisto J, Yaffe MB, Pittet MJ, Mora JR, Belkaid Y, Xavier RJ, Villablanca EJ. 2017 Nov 15. doi: 10.1038/mi.2017.91. PMID: 29139475
Mucosal Immunol. Retinoic acid takes effector T cells to the gallows: P2X7, the molecular hangman. Das S, Villablanca EJ. 2017 Jul;10(4):884-886. doi: 10.1038/mi.2016.117. Epub 2017 Jan 4. PMID: 28051090
Mol Cell Proteomics. Tracing Cellular Origin of Human Exosomes Using Multiplex Proximity Extension Assays. Larssen P, Wik L, Czarnewski P, Eldh M, Löf L, Ronquist KG, Dubois L, Freyhult E, Gallant CJ, Oelrich J, Larsson A, Ronquist G, Villablanca EJ, Landegren U, Gabrielsson S, Kamali-Moghaddam M. 2017 Mar;16(3):502-511. doi: 10.1074/mcp.M116.064725. Epub 2017 Jan 22. PMID: 28111361
Nutrients. Retinoic Acid and Its Role in Modulating Intestinal Innate Immunity. Czarnewski P, Das S, Parigi SM, Villablanca EJ. 2017 Jan 13;9(1). pii: E68. doi: 10.3390/nu9010068. Review. PMID: 28098786
2016
Immunity. Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk. Lassen KG, McKenzie CI, Mari M, Murano T, Begun J, Baxt LA, Goel G, Villablanca EJ, Kuo SY, Huang H, Macia L, Bhan AK, Batten M, Daly MJ, Reggiori F, Mackay CR, Xavier RJ. 2016 Jun 21;44(6):1392-405. doi: 10.1016/j.immuni.2016.05.007. Epub 2016 Jun 7. PMID: 27287411
Annu Rev Immune. Mechanisms of Pediatric Inflammatory Bowel Disease. Peloquin JM, Goel G, Villablanca EJ, Xavier RJ. 2016 May 20;34:31-64. doi: 10.1146/annurev-immunol-032414-112151. PMID: 27168239
2015
Front Immunol. Breast Milk and Solid Food Shaping Intestinal Immunity. Parigi SM, Eldh M, Larssen P, Gabrielsson S, Villablanca EJ. 2015 Aug 19;6:415. doi: 10.3389/fimmu.2015.00415. eCollection 2015 Aug 19. Review. PMID: 26347740
Nat Commun. Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst. Graham DB, Becker CE, Doan A, Goel G, Villablanca EJ, Knights D, Mok A, Ng AC, Doench JG, Root DE, Clish CB, Xavier RJ. 2015 Jul 21;6:7838. doi: 10.1038/ncomms8838. PMID: 26194095
Cell Rep. Integrated Genomics of Crohn’s Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy. Begun J, Lassen KG, Jijon HB, Baxt LA, Goel G, Heath RJ, Ng A, Tam JM, Kuo SY, Villablanca EJ, Fagbami L, Oosting M, Kumar V, Schenone M, Carr SA, Joosten LA, Vyas JM, Daly MJ, Netea MG, Brown GD, Wijmenga C, Xavier RJ. 2015 Jun 30;11(12):1905-18. doi: 10.1016/j.celrep.2015.05.045. Epub 2015 Jun 18. PMID: 26095365
2014
Proc Natl Acad Sci U S A. Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defence. Lassen KG, Kuballa P, Conway KL, Patel KK, Becker CE, Peloquin JM, Villablanca EJ, Norman JM, Liu TC, Heath RJ, Becker ML, Fagbami L, Horn H, Mercer J, Yilmaz OH, Jaffe JD, Shamji AF, Bhan AK, Carr SA, Daly MJ, Virgin HW, Schreiber SL, Stappenbeck TS, Xavier RJ. 2014 May 27;111(21):7741-6. doi: 10.1073/pnas.1407001111. Epub 2014 May 12. PMID: 24821797
Gut. β7 integrins are required to give rise to intestinal mononuclear phagocytes with tolerogenic potential. Villablanca EJ, De Calisto J, Torregrosa Paredes P, Cassani B, Nguyen DD, Gabrielsson S, Mora JR.2014 Sep;63(9):1431-40. doi: 10.1136/gutjnl-2013-305386. Epub 2013 Sep 12. PMID: 24030488
2013
Gastroenterology. Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection. Conway KL, Kuballa P, Song JH, Patel KK, Castoreno AB, Yilmaz OH, Jijon HB, Zhang M, Aldrich LN, Villablanca EJ, Peloquin JM, Goel G, Lee IA, Mizoguchi E, Shi HN, Bhan AK, Shaw SY, Schreiber SL, Virgin HW, Shamji AF, Stappenbeck TS, Reinecker HC, Xavier RJ. 2013 Dec;145(6):1347-57. doi: 10.1053/j.gastro.2013.08.035. Epub 2013 Aug 21. PMID: 23973919
J Exp Med. The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils. Raccosta L, Fontana R, Maggioni D, Lanterna C, Villablanca EJ, Paniccia A, Musumeci A, Chiricozzi E, Trincavelli ML, Daniele S, Martini C, Gustafsson JA, Doglioni C, Feo SG, Leiva A, Ciampa MG, Mauri L, Sensi C, Prinetti A, Eberini I, Mora JR, Bordignon C, Steffensen KR, Sonnino S, Sozzani S, Traversari C, Russo V. 2013 Aug 26;210(9):1711-28. doi: 10.1084/jem.20130440. Epub 2013 Jul 29. PMID: 23897983
Gastroenterology. Card9 mediates intestinal epithelial cell restitution, T-helper 17 responses, and control of bacterial infection in mice. Sokol H, Conway KL, Zhang M, Choi M, Morin B, Cao Z, Villablanca EJ, Li C, Wijmenga C, Yun SH, Shi HN, Xavier RJ. 2013 Sep;145(3):591-601.e3. doi: 10.1053/j.gastro.2013.05.047. Epub 2013 May 31. PMID: 23732773
Oncoimmunology. Retinoic acid-producing DCs and gut-tropic FOXP3+ regulatory T cells in the induction of oral tolerance. Villablanca EJ. 2013 Feb 1;2(2):e22987. PMID: 23526672
2012
Eur J Immunol. FcγRI (CD64): an identity card for intestinal macrophages. De Calisto J, Villablanca EJ, Mora JR. 2012 Dec;42(12):3136-40. doi: 10.1002/eji.201243061. PMID: 23255010
Cell. Gut immune maturation depends on colonization with a host-specific microbiota. Chung H, Pamp SJ, Hill JA, Surana NK, Edelman SM, Troy EB, Reading NC, Villablanca EJ, Wang S, Mora JR, Umesaki Y, Mathis D, Benoist C, Relman DA, Kasper DL. 2012 Jun 22;149(7):1578-93. doi: 10.1016/j.cell.2012.04.037. PMID: 22726443
Gastroenterology. Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice. Nguyen DD, Wurbel MA, Goettel JA, Eston MA, Ahmed OS, Marin R, Boden EK, Villablanca EJ, Paidassi H, Ahuja V, Reinecker HC, Fiebiger E, Lacy-Hulbert A, Horwitz BH, Mora JR, Snapper SB. 2012 Sep;143(3):719-29.e1-2. doi: 10.1053/j.gastro.2012.06.008. Epub 2012 Jun 15. PMID: 22710191
Mol Aspects Med. Vitamin A and immune regulation: role of retinoic acid in gut-associated dendritic cell education, immune protection and tolerance. Cassani B, Villablanca EJ, De Calisto J, Wang S, Mora JR. 2012 Feb;33(1):63-76. doi: 10.1016/j.mam.2011.11.001. Epub 2011 Nov 22. Review. PMID: 22120429
Gastroenterology. Gut-tropic T cells that express integrin α4β7 and CCR9 are required for induction of oral immune tolerance in mice. Cassani B, Villablanca EJ, Quintana FJ, Love PE, Lacy-Hulbert A, Blaner WS, Sparwasser T, Snapper SB, Weiner HL, Mora JR. 2011 Dec;141(6):2109-18. doi: 10.1053/j.gastro.2011.09.015. Epub 2011 Sep 16. PMID: 21925467
Methods Mol Biol. T-cell homing to the gut mucosa: general concepts and methodological considerations. De Calisto J, Villablanca EJ, Wang S, Bono MR, Rosemblatt M, Mora JR. 2012;757:411-34. doi: 10.1007/978-1-61779-166-6_24. PMID: 21909925
2011
J Immunol. Vitamin A deficiency impairs vaccine-elicited gastrointestinal immunity. Kaufman DR, De Calisto J, Simmons NL, Cruz AN, Villablanca EJ, Mora JR, Barouch DH. 2011 Aug 15;187(4):1877-83. doi: 10.4049/jimmunol.1101248. Epub 2011 Jul 15. PMID: 21765014
J Immunol. MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties. Wang S, Villablanca EJ, De Calisto J, Gomes DC, Nguyen DD, Mizoguchi E, Kagan JC, Reinecker HC, Hacohen N, Nagler C, Xavier RJ, Rossi-Bergmann B, Chen YB, Blomhoff R, Snapper SB, Mora JR. 2011 Jul 1;187(1):141-50. doi: 10.4049/jimmunol.1003740. Epub 2011 Jun 6. PMID: 21646294
Gastroenterology. MyD88 and retinoic acid signaling pathways interact to modulate gastrointestinal activities of dendritic cells. Villablanca EJ, Wang S, de Calisto J, Gomes DC, Kane MA, Napoli JL, Blaner WS, Kagechika H, Blomhoff R, Rosemblatt M, Bono MR, von Andrian UH, Mora JR. 2011 Jul;141(1):176-85. doi: 10.1053/j.gastro.2011.04.010. Epub 2011 Apr 16. PMID: 21596042
Gastroenterology. Blocking lymphocyte localization to the gastrointestinal mucosa as a therapeutic strategy for inflammatory bowel diseases. Villablanca EJ, Cassani B, von Andrian UH, Mora JR. 2011 May;140(6):1776-84. doi: 10.1053/j.gastro.2011.02.015. PMID: 21530744
J Vis Exp. Competitive homing assays to study gut-tropic t cell migration. Villablanca EJ, Mora JR. 2011 Mar 1;(49). pii: 2619. doi: 10.3791/2619. PMID: 21403633
2010
BMC Dev Biol. Molecular dissection of the migrating posterior lateral line primordium during early development in zebrafish. Gallardo VE, Liang J, Behra M, Elkahloun A, Villablanca EJ, Russo V, Allende ML, Burgess SM. 2010 Dec 13;10:120. doi: 10.1186/1471-213X-10-120. PMID: 21144052
Nat Med. Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses. Villablanca EJ, Raccosta L, Zhou D, Fontana R, Maggioni D, Negro A, Sanvito F, Ponzoni M, Valentinis B, Bregni M, Prinetti A, Steffensen KR, Sonnino S, Gustafsson JA, Doglioni C, Bordignon C, Traversari C, Russo V. 2010 Jan;16(1):98-105. doi: 10.1038/nm.2074. Epub 2009 Dec 27. PMID: 20037595
2009
BMC Dev Biol. The zebrafish prospero homolog prox1 is required for mechanosensory hair cell differentiation and functionality in the lateral line. Pistocchi A, Feijóo CG, Cabrera P, Villablanca EJ, Allende ML, Cotelli F. 2009 Nov 30;9:58. doi: 10.1186/1471-213X-9-58. PMID: 19948062
Gastroenterology. Gut homing receptors on CD8 T cells are retinoic acid dependent and not maintained by liver dendritic or stellate cells. Eksteen B, Mora JR, Haughton EL, Henderson NC, Lee-Turner L, Villablanca EJ, Curbishley SM, Aspinall AI, von Andrian UH, Adams DH. 2009 Jul;137(1):320-9. doi: 10.1053/j.gastro.2009.02.046. Epub 2009 Feb 21. PMID: 19233184
2008
Eur J Immunol. A two-step model for Langerhans cell migration to skin-draining LN. Villablanca EJ, Mora JR. 2008 Nov;38(11):2975-80. doi: 10.1002/eji.200838919. Review. PMID: 18991275
J Leukoc Biol. Selected natural and synthetic retinoids impair CCR7- and CXCR4-dependent cell migration in vitro and in vivo. Villablanca EJ, Zhou D, Valentinis B, Negro A, Raccosta L, Mauri L, Prinetti A, Sonnino S, Bordignon C, Traversari C, Russo V. 2008 Sep;84(3):871-9. doi: 10.1189/jlb.0108047. Epub 2008 May 30. PMID: 18515328
Histol Histopathol. Dendritic cell migration and lymphocyte homing imprinting. Villablanca EJ, Russo V, Mora JR. 2008 Jul;23(7):897-910. doi: 10.14670/HH-23.897. Review. PMID: 18437688
2007
J Immunol. Abrogation of prostaglandin E2/EP4 signaling impairs the development of rag1+ lymphoid precursors in the thymus of zebrafish embryos. Villablanca EJ, Pistocchi A, Court FA, Cotelli F, Bordignon C, Allende ML, Traversari C, Russo V. 2007 Jul 1;179(1):357-64. PMID: 17579056
2006
Dev Biol. Proneural gene requirement for hair cell differentiation in the zebrafish lateral line. Sarrazin AF, Villablanca EJ, Nuñez VA, Sandoval PC, Ghysen A, Allende ML. 2006 Jul 15;295(2):534-45. Epub 2006 Apr 4. PMID: 16678150
Dev Dyn. Control of cell migration in the zebrafish lateral line: implication of the gene “tumour-associated calcium signal transducer,” tasted. Villablanca EJ, Renucci A, Sapède D, Lec V, Soubiran F, Sandoval PC, Dambly-Chaudière C, Ghysen A, Allende ML. 2006 Jun;235(6):1578-88. PMID: 16552761
