Publications

Word soup MEDLINE copy

2018


J Allergy Clin Immunol. Vitamin D downregulates the IL-23 receptor pathway in human mucosal ILC3. Konya V, Czarnewski P, Forkel M, Rao A, Kokkinou E, Villablanca EJ, Almer S, Lindforss U, Friberg D, Höög C, Bergman P, Mjösberg J. 2018 Jan;141(1):279-292. doi: 10.1016/j.jaci.2017.01.045. Epub 2017 Apr 20.

Sci Rep. Flt3 ligand expands bona fide innate lymphoid cell precursors in vivo.
Parigi SM, Czarnewski P, Das S, Steeg C, Brockmann L, Fernandez-Gaitero S, Yman V, Forkel M, Höög C, Mjösberg J, Westerberg L, Färnert A, Huber S, Jacobs T, Villablanca EJ.
2018 Jan 9;8(1):154. doi: 10.1038/s41598-017-18283-0. PMID: 29317685

2017


Mucosal Immunol. Intestinal epithelial cell-specific RARα depletion results in aberrant epithelial cell homeostasis and underdeveloped immune system. Jijon HB, Suarez-Lopez L, Diaz OE, Das S, De Calisto J, Yaffe MB, Pittet MJ, Mora JR, Belkaid Y, Xavier RJ, Villablanca EJ. 2017 Nov 15. doi: 10.1038/mi.2017.91. PMID: 29139475

Mucosal Immunol. Retinoic acid takes effector T cells to the gallows: P2X7, the molecular hangman. Das SVillablanca EJ. 2017 Jul;10(4):884-886. doi: 10.1038/mi.2016.117. Epub 2017 Jan 4. PMID: 28051090

Mol Cell Proteomics. Tracing Cellular Origin of Human Exosomes Using Multiplex Proximity Extension Assays. Larssen P, Wik L, Czarnewski P, Eldh M, Löf L, Ronquist KG, Dubois L, Freyhult E, Gallant CJ, Oelrich J, Larsson A, Ronquist G, Villablanca EJ, Landegren U, Gabrielsson S, Kamali-Moghaddam M. 2017 Mar;16(3):502-511. doi: 10.1074/mcp.M116.064725. Epub 2017 Jan 22. PMID: 28111361

Nutrients. Retinoic Acid and Its Role in Modulating Intestinal Innate Immunity. Czarnewski P, Das S, Parigi SMVillablanca EJ. 2017 Jan 13;9(1). pii: E68. doi: 10.3390/nu9010068. Review. PMID: 28098786

 

2016


Immunity. Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk. Lassen KG, McKenzie CI, Mari M, Murano T, Begun J, Baxt LA, Goel G, Villablanca EJ, Kuo SY, Huang H, Macia L, Bhan AK, Batten M, Daly MJ, Reggiori F, Mackay CR, Xavier RJ. 2016 Jun 21;44(6):1392-405. doi: 10.1016/j.immuni.2016.05.007. Epub 2016 Jun 7. PMID: 27287411

Annu Rev Immune. Mechanisms of Pediatric Inflammatory Bowel Disease. Peloquin JM, Goel G, Villablanca EJ, Xavier RJ. 2016 May 20;34:31-64. doi: 10.1146/annurev-immunol-032414-112151. PMID: 27168239

 

2015


Front Immunol. Breast Milk and Solid Food Shaping Intestinal Immunity. Parigi SM, Eldh M, Larssen P, Gabrielsson S, Villablanca EJ. 2015 Aug 19;6:415. doi: 10.3389/fimmu.2015.00415. eCollection 2015 Aug 19. Review. PMID: 26347740

Nat Commun. Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst. Graham DB, Becker CE, Doan A, Goel G, Villablanca EJ, Knights D, Mok A, Ng AC, Doench JG, Root DE, Clish CB, Xavier RJ. 2015 Jul 21;6:7838. doi: 10.1038/ncomms8838. PMID: 26194095

Cell Rep. Integrated Genomics of Crohn’s Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy. Begun J, Lassen KG, Jijon HB, Baxt LA, Goel G, Heath RJ, Ng A, Tam JM, Kuo SY, Villablanca EJ, Fagbami L, Oosting M, Kumar V, Schenone M, Carr SA, Joosten LA, Vyas JM, Daly MJ, Netea MG, Brown GD, Wijmenga C, Xavier RJ. 2015 Jun 30;11(12):1905-18. doi: 10.1016/j.celrep.2015.05.045. Epub 2015 Jun 18. PMID: 26095365

 

2014


Proc Natl Acad Sci U S A. Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defence. Lassen KG, Kuballa P, Conway KL, Patel KK, Becker CE, Peloquin JM, Villablanca EJ, Norman JM, Liu TC, Heath RJ, Becker ML, Fagbami L, Horn H, Mercer J, Yilmaz OH, Jaffe JD, Shamji AF, Bhan AK, Carr SA, Daly MJ, Virgin HW, Schreiber SL, Stappenbeck TS, Xavier RJ. 2014 May 27;111(21):7741-6. doi: 10.1073/pnas.1407001111. Epub 2014 May 12. PMID: 24821797

Gut. β7 integrins are required to give rise to intestinal mononuclear phagocytes with tolerogenic potential. Villablanca EJ, De Calisto J, Torregrosa Paredes P, Cassani B, Nguyen DD, Gabrielsson S, Mora JR.2014 Sep;63(9):1431-40. doi: 10.1136/gutjnl-2013-305386. Epub 2013 Sep 12. PMID: 24030488

 

2013


Gastroenterology. Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection. Conway KL, Kuballa P, Song JH, Patel KK, Castoreno AB, Yilmaz OH, Jijon HB, Zhang M, Aldrich LN, Villablanca EJ, Peloquin JM, Goel G, Lee IA, Mizoguchi E, Shi HN, Bhan AK, Shaw SY, Schreiber SL, Virgin HW, Shamji AF, Stappenbeck TS, Reinecker HC, Xavier RJ. 2013 Dec;145(6):1347-57. doi: 10.1053/j.gastro.2013.08.035. Epub 2013 Aug 21. PMID: 23973919

J Exp Med. The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils. Raccosta L, Fontana R, Maggioni D, Lanterna C, Villablanca EJ, Paniccia A, Musumeci A, Chiricozzi E, Trincavelli ML, Daniele S, Martini C, Gustafsson JA, Doglioni C, Feo SG, Leiva A, Ciampa MG, Mauri L, Sensi C, Prinetti A, Eberini I, Mora JR, Bordignon C, Steffensen KR, Sonnino S, Sozzani S, Traversari C, Russo V. 2013 Aug 26;210(9):1711-28. doi: 10.1084/jem.20130440. Epub 2013 Jul 29. PMID: 23897983

Gastroenterology. Card9 mediates intestinal epithelial cell restitution, T-helper 17 responses, and control of bacterial infection in mice. Sokol H, Conway KL, Zhang M, Choi M, Morin B, Cao Z, Villablanca EJ, Li C, Wijmenga C, Yun SH, Shi HN, Xavier RJ. 2013 Sep;145(3):591-601.e3. doi: 10.1053/j.gastro.2013.05.047. Epub 2013 May 31. PMID: 23732773

Oncoimmunology. Retinoic acid-producing DCs and gut-tropic FOXP3+ regulatory T cells in the induction of oral tolerance. Villablanca EJ. 2013 Feb 1;2(2):e22987. PMID: 23526672

 

2012


Eur J Immunol. FcγRI (CD64): an identity card for intestinal macrophages. De Calisto J, Villablanca EJ, Mora JR. 2012 Dec;42(12):3136-40. doi: 10.1002/eji.201243061. PMID: 23255010

Cell. Gut immune maturation depends on colonization with a host-specific microbiota. Chung H, Pamp SJ, Hill JA, Surana NK, Edelman SM, Troy EB, Reading NC, Villablanca EJ, Wang S, Mora JR, Umesaki Y, Mathis D, Benoist C, Relman DA, Kasper DL. 2012 Jun 22;149(7):1578-93. doi: 10.1016/j.cell.2012.04.037. PMID: 22726443

Gastroenterology. Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice. Nguyen DD, Wurbel MA, Goettel JA, Eston MA, Ahmed OS, Marin R, Boden EK, Villablanca EJ, Paidassi H, Ahuja V, Reinecker HC, Fiebiger E, Lacy-Hulbert A, Horwitz BH, Mora JR, Snapper SB. 2012 Sep;143(3):719-29.e1-2. doi: 10.1053/j.gastro.2012.06.008. Epub 2012 Jun 15. PMID: 22710191

Mol Aspects Med. Vitamin A and immune regulation: role of retinoic acid in gut-associated dendritic cell education, immune protection and tolerance. Cassani B, Villablanca EJ, De Calisto J, Wang S, Mora JR. 2012 Feb;33(1):63-76. doi: 10.1016/j.mam.2011.11.001. Epub 2011 Nov 22. Review. PMID: 22120429

Gastroenterology. Gut-tropic T cells that express integrin α4β7 and CCR9 are required for induction of oral immune tolerance in mice. Cassani B, Villablanca EJ, Quintana FJ, Love PE, Lacy-Hulbert A, Blaner WS, Sparwasser T, Snapper SB, Weiner HL, Mora JR. 2011 Dec;141(6):2109-18. doi: 10.1053/j.gastro.2011.09.015. Epub 2011 Sep 16. PMID: 21925467

Methods Mol Biol. T-cell homing to the gut mucosa: general concepts and methodological considerations. De Calisto J, Villablanca EJ, Wang S, Bono MR, Rosemblatt M, Mora JR. 2012;757:411-34. doi: 10.1007/978-1-61779-166-6_24. PMID: 21909925

 

2011


J Immunol. Vitamin A deficiency impairs vaccine-elicited gastrointestinal immunity. Kaufman DR, De Calisto J, Simmons NL, Cruz AN, Villablanca EJ, Mora JR, Barouch DH. 2011 Aug 15;187(4):1877-83. doi: 10.4049/jimmunol.1101248. Epub 2011 Jul 15. PMID: 21765014

J Immunol. MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties. Wang S, Villablanca EJ, De Calisto J, Gomes DC, Nguyen DD, Mizoguchi E, Kagan JC, Reinecker HC, Hacohen N, Nagler C, Xavier RJ, Rossi-Bergmann B, Chen YB, Blomhoff R, Snapper SB, Mora JR. 2011 Jul 1;187(1):141-50. doi: 10.4049/jimmunol.1003740. Epub 2011 Jun 6. PMID: 21646294

Gastroenterology. MyD88 and retinoic acid signaling pathways interact to modulate gastrointestinal activities of dendritic cells. Villablanca EJ, Wang S, de Calisto J, Gomes DC, Kane MA, Napoli JL, Blaner WS, Kagechika H, Blomhoff R, Rosemblatt M, Bono MR, von Andrian UH, Mora JR. 2011 Jul;141(1):176-85. doi: 10.1053/j.gastro.2011.04.010. Epub 2011 Apr 16. PMID: 21596042

Gastroenterology. Blocking lymphocyte localization to the gastrointestinal mucosa as a therapeutic strategy for inflammatory bowel diseases. Villablanca EJ, Cassani B, von Andrian UH, Mora JR. 2011 May;140(6):1776-84. doi: 10.1053/j.gastro.2011.02.015. PMID: 21530744

J Vis Exp. Competitive homing assays to study gut-tropic t cell migration. Villablanca EJ, Mora JR. 2011 Mar 1;(49). pii: 2619. doi: 10.3791/2619. PMID: 21403633

 

2010


BMC Dev Biol. Molecular dissection of the migrating posterior lateral line primordium during early development in zebrafish. Gallardo VE, Liang J, Behra M, Elkahloun A, Villablanca EJ, Russo V, Allende ML, Burgess SM. 2010 Dec 13;10:120. doi: 10.1186/1471-213X-10-120. PMID: 21144052

Nat Med. Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses. Villablanca EJ, Raccosta L, Zhou D, Fontana R, Maggioni D, Negro A, Sanvito F, Ponzoni M, Valentinis B, Bregni M, Prinetti A, Steffensen KR, Sonnino S, Gustafsson JA, Doglioni C, Bordignon C, Traversari C, Russo V. 2010 Jan;16(1):98-105. doi: 10.1038/nm.2074. Epub 2009 Dec 27. PMID: 20037595

 

2009


BMC Dev Biol. The zebrafish prospero homolog prox1 is required for mechanosensory hair cell differentiation and functionality in the lateral line. Pistocchi A, Feijóo CG, Cabrera P, Villablanca EJ, Allende ML, Cotelli F. 2009 Nov 30;9:58. doi: 10.1186/1471-213X-9-58. PMID: 19948062

Gastroenterology. Gut homing receptors on CD8 T cells are retinoic acid dependent and not maintained by liver dendritic or stellate cells. Eksteen B, Mora JR, Haughton EL, Henderson NC, Lee-Turner L, Villablanca EJ, Curbishley SM, Aspinall AI, von Andrian UH, Adams DH. 2009 Jul;137(1):320-9. doi: 10.1053/j.gastro.2009.02.046. Epub 2009 Feb 21. PMID: 19233184

 

2008


Eur J Immunol. A two-step model for Langerhans cell migration to skin-draining LN. Villablanca EJ, Mora JR. 2008 Nov;38(11):2975-80. doi: 10.1002/eji.200838919. Review. PMID: 18991275

J Leukoc Biol. Selected natural and synthetic retinoids impair CCR7- and CXCR4-dependent cell migration in vitro and in vivo. Villablanca EJ, Zhou D, Valentinis B, Negro A, Raccosta L, Mauri L, Prinetti A, Sonnino S, Bordignon C, Traversari C, Russo V. 2008 Sep;84(3):871-9. doi: 10.1189/jlb.0108047. Epub 2008 May 30. PMID: 18515328

Histol Histopathol. Dendritic cell migration and lymphocyte homing imprinting. Villablanca EJ, Russo V, Mora JR. 2008 Jul;23(7):897-910. doi: 10.14670/HH-23.897. Review. PMID: 18437688

 

2007


J Immunol. Abrogation of prostaglandin E2/EP4 signaling impairs the development of rag1+ lymphoid precursors in the thymus of zebrafish embryos. Villablanca EJ, Pistocchi A, Court FA, Cotelli F, Bordignon C, Allende ML, Traversari C, Russo V. 2007 Jul 1;179(1):357-64. PMID: 17579056

 

2006


Dev Biol. Proneural gene requirement for hair cell differentiation in the zebrafish lateral line. Sarrazin AF, Villablanca EJ, Nuñez VA, Sandoval PC, Ghysen A, Allende ML. 2006 Jul 15;295(2):534-45. Epub 2006 Apr 4. PMID: 16678150

Dev Dyn. Control of cell migration in the zebrafish lateral line: implication of the gene “tumour-associated calcium signal transducer,” tasted. Villablanca EJ, Renucci A, Sapède D, Lec V, Soubiran F, Sandoval PC, Dambly-Chaudière C, Ghysen A, Allende ML. 2006 Jun;235(6):1578-88. PMID: 16552761