CONTACT INFORMATION

YUQING ZHOU

MASTER STUDENT

Assessing the toxicological impact of peroxisome proliferator-activated receptors (PPARs) signaling activity in the intestine using zebrafish as the research model. Inflammatory Bowel Disease (IBD) comprises immune-mediated disorders causing chronic inflammation in the gastrointestinal tract. While the exact cause is unknown, environmental factors, including pollutants and dietary compounds, may impact intestinal regeneration. Amid this complexity, PPARs, a class of nuclear receptors activated by lipid metabolites, emerge as significant regulators. PPARs, like PPARα and PPARγ, have been linked to anti-inflammatory functions and considered therapeutic targets. However, the role of PPARδ in inflammation is ambiguous, with conflicting phenotypes observed in different tissues. This underscores the crucial involvement of PPARs, particularly PPARδ, in the intricate immune responses associated with IBD, prompting further exploration of their role in this complex disease.